School of Pharmaceutical Sciences, University Science Malaysia, Minden, Penang, Malaysia. hhang@usm.my
The effects of Eurycoma longifolia Jack were studied on the sexual qualities of middle aged male rats after dosing them with 0.5 g/kg of various fractions of E. longifolia whilst the control group received 3 ml/kg of normal saline daily for 12 weeks. Results showed than E. longifolia Jack enhanced the sexual qualities of the middle aged male rats by decreasing their hesitation time as compared to controls with various fractions of E. longifolia Jack produced 865-916 (91-96), 860-914 (92-98), 850-904 (93-99), 854-890 (95-99), 844-880 (94-98), 840-875 (94-98), 830-870 (94-98), 825-860 (94-98), 820-850 (96-99), 800-840 (93-98), 750-795 (94-99) and 650-754 sec (82-95%) in contrast to controls which produced 950 (100), 934 (100), 910 (100), 900 (100), 895 (100), 890 (100), 885 (100), 880 (100), 855 (100), 860 (100), 800 (100) and 790 sec (100%) throughout the investigation period. Besides these, there was a transient increase in the % of the male rats responding to the right choice after chronic administration of 0.5 g/kg E. longifolia Jack, with more than 50% of the male rats scored right choice after 2 weeks post-treatment and the effect was more prominent at the dose of the observation period. However, there was no sexual enhancement of the middle aged male rats which consumed normal saline since only 45-55% of the male rats responded to right choice throughout the investigation period. Hence, this study shows that E. longifolia Jack enhanced the sexual qualities of the middle aged male rats, further supports the folkuse of E. longifolia Jack as an aphrodisiac.
Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats.
Ang HH, Lee KL.
School of Pharmaceutical Sciences, University Science
Malaysia, Minden, 11800, Penang, Malaysia.
hhang@usm.my
The effects of various fractions of Eurycoma
longifolia Jack were studied on the orientation
activities of the inbred, adult middle-aged
Sprague-Dawley rats, 9 months old and retired breeders
towards the receptive females (anogenital sniffing,
licking, mounting), the environment (climbing, raring,
exploration), themselves (nongenital grooming, genital
grooming) and mobility (restricted, unrestricted)
after treating these subjects twice daily for 10 days.
Results showed that subjects treated with 800 mg/kg of
E. longifolia Jack increased orientation activities
towards the receptive females (anogenital sniffing,
licking and mounting), increased genital grooming
towards themselves and restricted movements to a
particular area of the cage but decreased interest in
the external environment (climbing, raring,
exploration) as compared with the controls during the
investigation period. In conclusion, this study gives
further evidences that different fractions of E.
longifolia Jack modified the orientation activities of
the middle-aged male rats.
PMID: 12685506 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12685506&
ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
Eurycoma longifolia Jack enhances libido in sexually experienced male rats.
Ang HH, Sim MK.
School of Pharmaceutical Sciences, University of
Science Malaysia, Penang, Malaysia.
The effects of Eurycoma longifolia Jack were studied
on the libido of sexually experienced male rats after
dosing them with 200, 400 and 800 mg/kg body weight
twice daily of different fractions of E. longifolia
Jack for 10 days. Results showed that E. longifolia
Jack produced a dose-dependent increase in mounting
frequency of the treated animals with 400 mg/kg of
chloroform, methanol, water and butanol fractions
resulting in mounting frequencies of 5.3 +/- 1.2, 4.9
+/- 0.7, 4.8 +/- 0.7 and 5.2 +/- 0.1, and 800 mg/kg
further increased them to 5.4 +/- 0.8, 5.4 +/- 0.8,
5.2 +/- 0.6 and 5.3 +/- 0.2 respectively but there
were no erections, intromissions, ejaculations or
seminal emissions during the 20-min observation period
which allowed for the measurement of sexual arousal
reflected by mounting frequency uninfluenced by other
behavioural components. This study provides evidence
that E. longifolia Jack is a potent stimulator of
sexual arousal in sexually vigorous male rats in the
absence of feedback from genital sensation.
PMID: 9353636 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=9353636
&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
Eurycoma longifolia Jack enhances sexual motivation in
middle-aged male mice.
Ang HH, Lee KL, Kiyoshi M.
School of Pharmaceutical Sciences, University Science
Malaysia, Minden, Penang, Malaysia. hhang@usm.my
Eurycoma longifolia Jack was investigated for sexual
motivation activity in adult, middle-aged male mice
and in retired breeders, using the modified open field
and the modified runway choice methods. Each mouse
received 500 mg/kg of one of 4 fractions of E.
longifolia Jack, viz. chloroform, methanol, butanol,
and water, whereas the mice in the control and
yohimbine groups received 3 ml/kg of normal saline and
30 mg/kg of yohimbine daily respectively for 10 d. The
results show a transient increase in the percentage of
male mice responding to the right choice after chronic
consumption of the fractions with 50 percent of the
adult middle-aged male mice treated with E. longifolia
Jack and yohimbine scoring the right choice after 8
and 5 days post-treatment respectively. In conclusion,
this study has shown that E. longifolia Jack continues
to enhance sexual motivation in adult, middle-aged
male mice and in retired breeders.
PMID: 14964739 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=14964739&
ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
In vitro antimalarial activity of quassinoids from
Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates.
Ang HH, Chan KL, Mak JW.
Three quassinoids from the roots of Eurycoma
longifolia Jack were evaluated for antimalarial
activity against nine Plasmodium falciparum isolates
obtained from patients infected with
chloroquine-resistant malaria. The results indicated
that eurycomanol, eurycomanol
2-O-beta-D-glucopyranoside, and 13 beta,
18-dihydroeurycomanol possessed antimalarial activity
with IC50 values of 1.231-4.899 microM, 0.389-3.498
microM, and 0.504-2.343 microM, respectively, compared
with 0.323-0.774 microM for chloroquine.
PMID: 7753926 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=7753926&
ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Phytochemicals and the breakthrough of traditional
herbs in the management of sexual dysfunctions.
Adimoelja A.
School of medicine 'Hang Tuah' University, Teaching and Naval Hospital,Surabaya, Indonesia.
Traditional herbs have been a revolutionary
breakthrough in the management of erectile dysfunction
and have become known world-wide as an 'instant'
treatment. The modern view of the management of
erectile dysfunction subscribes to a single etiology,
i.e. the mechanism of erection. A large number of
pharmacological agents are orally consumed and
vasoactive agents inserted intraurethrally or injected
intrapenially to regain good erection. Modern
phytochemicals have developed from traditional herbs.
Phytochemicals focus their mechanism of healing action
to the root cause, i.e. the inability to control the
proper function of the whole body system. Hence
phytochemicals manage erectile dysfunction in the
frame of sexual dysfunction as a whole entity.
Protodioscin is a phytochemical agent derived from
Tribulus terrestris L plant, which has been clinically
proven to improve sexual desire and enhance erection
via the conversion of protodioscine to DHEA
(De-Hydro-Epi-Androsterone). Preliminary obser
PMID: 10849504 [PubMed - indexed for MEDLI vations
suggest that Tribulus terrestris L grown on different
soils does not consistently produce the active
component Protodioscin. Further photochemical studies
of many other herbal plants are needed to explain the
inconsistent results found with other herbal plants,
such as in diversities of Ginseng, Eurycoma
longifolia, Pimpinella pruacen, Muara puama, Ginkgo
biloba, Yohimbe etc. NE]
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=10849504&
ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
